Eleven towns in northern Italy are in lockdown after the outbreak.
Antonio Conte’s Inter hold a 2-0 advantage over the Bulgarian team from last week’s first-leg clash.
Inter were one of four Serie A clubs to postpone their game last weekend with more league matches affected this weekend.
Five games, including Juventus versus Inter in Turin on Sunday, will be played without any fans.
A number of Italian sporting events have been affected and on Wednesday it was announced that Ireland’s men’s and women’s Six Nations games against Italy in Dublin on 7 and 8 March would be postponed because of the virus.
Authorities have confirmed more than 300 cases and 12 deaths in Italy, the most recent a 70-year-old Lombardy resident who died after being taken to intensive care in Parma.
Four children in the country have also been infected.
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